Obesity During Pregnancy in Clinical PracticeAbout This Hardback Obesity in a mother during pregnancy can have a major impact on offspring development and maternal metabolism. Maternal obesity disrupts the processes of glucose homeostasis, fat oxidation, insulin resistance and amino acid synthesis. Such changes contribute to adverse outcomes, with increased odds of children born with congenital anomalies including spina bifida and neural tube defects. Other anomalies such as cleft lip and